I REUNION DE INVESTIGACION E INNOVACION EN SALUD VASCULAR: III JORNADA DE ESTUDIO EN HIPERTENSIÓN DEL EMBARAZO.

La interacción entre ciencias básicas con el desarrollo de la innovación con fines clínicos en el ámbito de la Fisiología Vascular será el foco de la I REUNION INVESTIGACION E INNOVACION EN SALUD VASCULAR, III JORNADA DE ESTUDIO EN HIPERTENSIÓN DEL EMBARAZO que se realizara en la ciudad de Chillan entre el 28 y 30 de abril del 2015.

Este evento reúne a académicos lideres en su área de expertise, provenientes de al menos 10 instituciones nacionales e internacionales, quienes analizaran los mas recientes hallazgos de sus investigaciones en el campo de la regeneración tisular, control de la función endotelial por hormonas, angiogénesis tumoral, disfunción endotelial y anti-angiogenesis en enfermedades cardiovasculares asociadas a pre-eclampsia; así como el desarrollo de innovaciones en estos temas con futura aplicabilidad clínica.

Sera también el espacio para que investigadores jóvenes, estudiantes, y comunidad en general puedan participar activamente de la discusión de estos hallazgos en un ambiente amigable, pero con alto contenido académico.

 Esperamos hacer de este evento un referente a nivel nacional, y para ello, su participación es muy importante para nosotros.

GRIVAS Health

Página web del evento: http://www.ubb.cl/patologiasembarazo/

Envío de Resúmenes

Los resúmenes deberán ser enviados al correo electrónico cescudero@ubiobio.cl hasta el 22 de Diciembre del 2014. Utilizando el formato anexo (ver página web). Adicionalmente, los estudiantes de pre y post-grado que presenten abstract deberán enviar una solicitud de beca al Dr. Marcelo Gonzalez al correo electrónico mgonzalezo@udec.cl

Artículo publicado en Frontiers in Pharmacology

Physiological mechanisms of vascular response induced by shear stress and effect of exercise in systemic and placental circulation

Iván Rodríguez^1,2 and Marcelo González^3,4*

• 1Faculty of Health Science, Universidad San Sebastián, Concepción, Chile
• 2PhD Program in Medical Sciences, Faculty of Medicine, Universidad de La Frontera, Temuco, Chile
• 3Vascular Physiology Laboratory, Department of Physiology, Faculty of Biological Sciences, Universidad de Concepción, Concepción, Chile
• 4Group of Research and Innovation in Vascular Health, Chillán, Chile

Physiological vascular function regulation is essential for cardiovascular health and depends on adequate control of molecular mechanisms triggered by endothelial cells in response to mechanical and chemical stimuli induced by blood flow. Endothelial dysfunction is one of the main risk factors of cardiovascular pathology, where the imbalance between the synthesis of vasodilator and vasoconstrictor molecules is common in the development of vascular disorders in systemic and placental circulation. In the placenta, an organ without autonomic innervations, the local control of vascular tone is critical for maintenance of fetal growth and mechanisms that underlie shear stress response induced by blood flow are essential during pregnancy. In this field, shear stress induced by moderate exercise is one of the most important mechanisms to improve vascular function through nitric oxide synthesis and stimulation of mechanical response of endothelial cells triggered by ion channels, caveolae, endothelial NO synthase, and vascular endothelial growth factor, among others. The demand for oxygen and nutrients by tissues and organs, especially in placentation and pregnancy, determines blood flow parameters, and physiological adaptations of vascular beds for covering metabolic requirements. In this regard, moderate exercise versus sedentarism shows potential benefits for improving vascular function associated with the enhancement of molecular mechanisms induced by shear stress. In this review, we collect evidence about molecular bases of physiological response to shear stress in order to highlight the relevance of moderate exercise-training for vascular health in adult and fetal life.

http://journal.frontiersin.org/Journal/10.3389/fphar.2014.00209/abstract

LFV en el Panamericano de Fisiología 2014

Con éxito presentaron sus trabajos los estudiantes Luz Valdivia y David Gallegos, en el marco del primer Congreso Panaméricano de Fisiología realizado en Foz de Iguazú el pasado mes de Agosto.

Los trabajos presentados fueron los siguientes:

Regulation of subcellular expression of hCAT-1 by high concentration of D-glucose in human fetal endothelium.

Gallegos D, Valdivia L, Rojas S, González M

Differential response to insulin in fetoplacental vasculature from Gestational Diabetes.

Valdivia L, Rojas S, Cid M, González M.

Endothelial dysfunction mechanism induced by high D-glucose in human endothelium.

Valenzuela, C., Rojas, S., González, M.

GRIVAS Health

Recientemente el Laboratorio de Fisiología vascular-UdeC ha pasado a formar parte del Grupo de Investigación e Innovación en Salud Vascular (GRIVAS Health), el cual busca dilucidas mecanismos y proponer estrategias terapéuticas a las principales enfermedades cardiovasculares que aquejan a nuestra población, desde un punto de vista inter-disciplinario.

Las principales noticias y eventos relacionados a este Grupo de Investigación serán difundidas a través de la página web creada para tal efecto:

http://grivashealth.cl/

También se pueden seguir las novedades a través de Facebook:

https://www.facebook.com/grivashealth

Nueva publicación: Lemon grass (Cymbopogon citratus (D.C) Stapf) polyphenols protect human umbilical vein endothelial cell (HUVECs) from oxidative damage induced by high glucose, hydrogen peroxide and oxidised low-density lipoprotein.

Lemon grass (Cymbopogon citratus (D.C) Stapf) polyphenols protect human umbilical vein endothelial cell (HUVECs) from oxidative damage induced by high glucose, hydrogen peroxide and oxidised low-density lipoprotein

Abstract

The aromatic herb Cymbopogon citratus Stapf is widely used in tropical and subtropical countries in cooking, as a herbal tea, and in traditional medicine for hypertension and diabetes. Some of its properties have been associated with the in vitro antioxidant effect of polyphenols isolated from their aerial parts. However, little is known about C. citratus effects on endothelial cells oxidative injury. Using chromatographic procedures, a polyphenol-rich fraction was obtained from C. citratus (CCF) and their antioxidant properties were assessed by cooper-induced LDL oxidation assay. The main constituents of the active CCF, identified by high-performance liquid chromatography with diode-array detection and mass spectrometry (HPLC-DAD–MS), were chlorogenic acid, isoorientin and swertiajaponin. CCF 10 and 100 lg/ml diminishes reactive oxidative species (ROS) production in human umbilical vein endothelial cell (HUVECs), challenged with high D-glucose (60% inhibition), hydrogen peroxide (80% inhibition) or oxidised low-density lipoprotein (55% inhibition). CCF 10 or 100 lg/ml did not change nitric oxide (NO) production. However, CCF was able to inhibit vasoconstriction induced by the thromboxane A receptor agonist U46619, which suggest a NO-independent vasodilatador effect on blood vessels. Our results suggest that lemon grass antioxidant properties might prevent endothelial dysfunction associated to an oxidative imbalance promoted by different oxidative stimuli.

Food Chemistry 151 (2014) 175–181